Barrett's esophagus (2024)

Precancerous conditions of the esophagus are changes to esophagus cells that make them more likely to develop into cancer. These conditions are not yet cancer. But if they aren't treated, there is a chance that these abnormal changes may become esophageal cancer.

Barrett's esophagus is the most common precancerous condition of the esophagus. In Barrett's esophagus, the normal cells lining the esophagus are replaced by cells that are like the lining of the stomach or intestine. This is called intestinal metaplasia. It is most often found in the gastroesophageal (GE) junction, which is where the esophagus joins the stomach.

People with Barrett's esophagus have a higher risk of developing abnormal cells, called dysplasia. Dysplasia describes how abnormal cells look. With low-grade dysplasia, the abnormal cells look somewhat different from normal cells. In high-grade dysplasia, the cells look very abnormal.

Dysplasia increases the risk of developing esophageal cancer. High-grade dysplasia increases the risk more than low-grade dysplasia or metaplasia.

Risk factors @(Model.HeadingTag)>

The main risk factor for developing Barrett's esophagus is gastroesophageal reflux disease (GERD). But not everyone with GERD will develop Barret esophagus, and not everyone with Barrett's esophagus will develop cancer.

Other risk factors for Barrett's esophagus include obesity, smoking and drinking alcohol.

Symptoms @(Model.HeadingTag)>

The symptoms of Barrett's esophagus may include:

  • stomach acid moving up into the esophagus (acid reflux)
  • heartburn
  • indigestion
  • chronic cough
  • hoarseness
  • having frequent lung infections (pneumonia)
  • back up of stomach contents into the mouth (regurgitation)
  • nausea and vomiting
  • changes to the teeth caused by regurgitation

Diagnosis @(Model.HeadingTag)>

If you have symptoms or your doctor thinks you might have Barrett’s esophagus, you will be sent for tests. Tests used to diagnose Barrett’s esophagus may include:

  • upper gastrointestinal (GI) endoscopy
  • biopsy
  • endoscopic ultrasound (EUS)

Treatments @(Model.HeadingTag)>

Treatments for Barrett’s esophagus may include:

Medicines such as proton pump inhibitors or H2 blockers may be given to treat GERD. These medicines control the amount of acid made in the stomach and reduce acid reflux.

Endoscopic mucosal resection (EMR) may be used to treat high-grade dysplasia in the esophagus. EMR removes the inner lining of the esophagus where there are abnormal cells.

Radiofrequency ablation (RFA) uses a high-frequency electrical current to remove abnormal cells. A balloon is connected to the end of an endoscope. The endoscope is inserted into the esophagus and the balloon is inflated so that the balloon can cover the area of abnormal cells. The radiofrequency current is given through the wall of the balloon.

Photodynamic therapy (PDT) uses a drug that makes cells sensitive to light. The drug is given intravenously, and the abnormal cells take it up from the blood stream. Using an endoscope inserted into the esophagus, the doctor exposes the abnormal cells to a light to destroy them.

Surgery to remove all or part of the esophagus is called an esophagectomy. It may be used to treat high-grade dysplasia in Barrett's esophagus, if there are very large or many areas of dysplasia. You must be healthy enough to have surgery.

Expert review and references

  • Johnston MH. Barrett Esophagus. eMedicine/Medscape; 2017: https://emedicine.medscape.com/article/171002-overview.

  • Tsottles ND, Lang P, Choflet AB. Esophageal cancer. Yarbro CH, Wujcki D, Holmes Gobel B, (eds.). Cancer Nursing: Principles and Practice. 8th ed. Burlington, MA: Jones and Bartlett Learning; 2018: 54: 1533-1563.

  • Posner MC, Minsky BD, Ilson DH. Cancer of the esophagus. DeVita VT Jr, Lawrence TS, Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2015: 45:574-612.

Barrett's esophagus (2024)

FAQs

Is Barrett's esophagus a serious condition? ›

Barrett's esophagus is associated with an increased risk of developing esophageal cancer. Although the risk of developing esophageal cancer is small, it's important to have regular checkups with careful imaging and extensive biopsies of the esophagus to check for precancerous cells (dysplasia).

What is the life expectancy of someone with Barrett's esophagus? ›

The mean life expectancy following a diagnosis of Barrett esophagus is 22 years; the lifetime risk of requiring intervention for high-grade dysplasia or esophageal adenocarcinoma is between one in five and one in six patients.

Can Barrett's esophagus be cured? ›

There is no cure for Barrett esophagus. However, medicines to reduce stomach acid and surgery called fundoplication may be used to treat the disease. Because Barrett esophagus tends to recur (come back), you will need continued monitoring.

How long before Barrett's esophagus turns to cancer? ›

Risk of progression depends on several factors

For example, one patient with non-dysplastic Barrett's esophagus develops cancer within a year of diagnosis, while another non-dysplastic patient remains cancer-free for decades. This variability in outcomes makes determining appropriate patient care very challenging.

What not to eat with Barrett's? ›

Avoiding trigger foods—such as chocolate, coffee, fried foods, peppermint, spicy foods, and carbonated beverages—can help reduce symptoms. These foods increase acid levels in the stomach. Doctors also recommend eating multiple small, frequent meals instead of a few large ones.

What are the red flag symptoms of Barrett's esophagus? ›

Symptoms of Barrett's oesophagus
  • persistent heartburn.
  • difficulty swallowing.
  • painful swallowing.
  • vomiting.
  • a sensation of fullness during eating.

What is the best drug for barrett's esophagus? ›

If you have Barrett's esophagus and gastroesophageal reflux disease (GERD), your doctor will treat you with acid-suppressing medicines called proton pump inhibitors (PPIs). These medicines can prevent further damage to your esophagus and, in some cases, heal existing damage.

Can omeprazole cure barrett's esophagus? ›

Conclusion: Treatment of Barrett's oesophagus with omeprazole 20 mg daily for periods of up to 6 years did not cause regression in the length of the Barrett's segment, but it did lead in over half of the patients to partial re-epithelialization in the form of squamous islands.

Is vitamin D good for barrett's esophagus? ›

After vitamin D supplementation, 25-hydroxyvitamin D levels rose significantly (median increase of 31.6 ng/mL, p<0.001). There were no significant changes in gene expression from esophageal squamous or Barrett's epithelium including 15-PGDH after supplementation.

What are symptoms of stage 1 esophageal cancer? ›

What are the symptoms of esophageal cancer?
  • Pain or a burning sensation behind the breastbone in the middle of the chest.
  • Heartburn.
  • Indigestion.
  • Decreased appetite.
  • Unexplained weight loss.
  • Blood in the stool (caused by esophageal bleeding)
  • A palpable lump under the skin in the chest.

What are the four stages of Barrett's esophagus? ›

Classifying Barrett's esophagus
  • Non-dysplastic metaplasia. This means there's no dysplasia yet and a low cancer risk.
  • Metaplasia with low-grade dysplasia. This means there's some dysplasia and cancer risk.
  • Metaplasia with high-grade dysplasia. This means there's significant dysplasia and cancer risk.
  • Carcinoma.

What are the odds of getting cancer from Barrett's esophagus? ›

Barrett's oesophagus can increase your risk of cancer of the oesophagus, although the risk is still small. Many people with Barrett's oesophagus do not develop cancer. Between 3 and 13 people out of 100 (between 3 and 13%) with Barrett's oesophagus in the UK will develop oesophageal adenocarcinoma in their lifetime.

Is Barrett's esophagus a critical illness? ›

Barrett's Oesophagus is not life-threatening on its own if your symptoms are mild to moderate, so life cover should be affordable and simple.

Why is Barrett's esophagus worrisome? ›

There is a risk of Barrett's esophagus becoming cancerous, so your condition may need to be monitored frequently. If there are precancerous cells (dysplasia) diagnosed in the Barrett's esophagus, endoscopic treatment is recommended and proven safe and effective for preventing progression to cancer.

Is Barrett's esophagus a disability? ›

This distinction is significant because the RO has recently added Barrett's esophagus, a new disability, to the service- connected disability. Thus, the 10 percent rating assigned represents an initial rating for Barrett's esophagus.

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